Collagen Supplementation and Gastrointestinal Health

The amino acids in collagen hydrolysate provide many health benefits to the gastrointestinal system.  They have been shown to improve gut integrity, support digestion and calm the digestive tract.   Many of the amino acids in collagen protect the gastrointestinal tract by regulating stomach acid secretion, preventing stomach ulcers, helping to heal gastrointestinal lining, reducing and preventing inflammation of the GI tract and helping to regulate digestion. One research study attempting to promote mucosal healing in ulcerative colitis found that by day 13 of supplementing with collagen hydrolysate rectal bleeding completely stopped.   Because bleeding stopped, there is indirect evidence that collagen hydrolysate supports mucosal regeneration, which improves gut health.  In the same study, there was also evidence found that collagen hydrolysate provided an anti-inflammatory effect as well as protection to the intestinal mucosa (1).   Many who suffer from leaky gut syndrome use collagen hydrolysate as a supplement to aid in symptom management as well. 

The amino acids glutamine, glycine, lysine, serine and threonine found in collagen hydrolysate all help with gastrointestinal health.  Glutamine aids in digestion as well as protects the lining of the gastrointestinal tract.  Glycine regulates the synthesis of bile, which is used to digest fats and may protect against stomach ulcers by minimizing unnecessary stomach acid secretion.  Lysine promotes the absorption of calcium from the intestines.  Serine aids in the digestive process.  The gastrointestinal tract needs threonine for normal functioning (2,3,4,5). 

There is minimal research currently out there on collagen supplementation and gastrointestinal health but the studies that are published show many benefits.  Supplementing with collagen hydrolysate may promote gut integrity, aid in digestion and help to calm the digestive system.


  1. Ramadass, S., Jabaris, SL., Perumal RK., HairulIslam VI., Gopinath, A., Madhan, B. Type I collagen and its daughter peptides for targeting mucosal healing in ulcerative colitis: A new treatment strategy.  European Journal of Pharmaceutical Science 2016 91:216-224.
  2. Escott-Stump, Sylvia, Mahan, Kathleen L., Krausse’s Food, Nutrition, and Diet Therapy
  5. Gersten Institute for Higher Medicine


Disclaimer: The information provided is for informational purposes only and is not intended to diagnose or treat any medical conditions. Nor is it intended to replace the advice or diagnosis of a medical professional. Individual results may vary.

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